La Vitamine D connecte la lumière aux gènes dans la sclérose en plaques

摘要

The relationship between sunlight exposure andthe incidence of multiple sclerosis and the understanding ofimmunomodulatory effects of vitamin D triggered, in recentyears, a broad range of investigations. Immunological studiesperformed in vitro and in vivo have demonstrated how tolerogenicvitamin D can be. Epidemiological studies confirmed anincreased incidence of multiple sclerosis in vitamin D deficientsubjects and signs of increased disease activity in such MSpatients. Although small-scale observational studies have suggesteda beneficial impact of vitamin D supplementation on theincidence and severity of multiple sclerosis, large scale clinicaltrials remain warranted to confirm these preliminary results.